COVID-19 and Testis: A Systematic Review

1. Abstract
Corona Virus Disease 2019 (COVID-19), triggered by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has created a global pandemic. As of November 20, 2020, SARSCoV- 2 is known to have 56,623,643 persons infected globally, and 1,355,963 deaths have been reported worldwide. Angiotensin- Converting Enzyme 2 (ACE2) has been found to be one of the major receptors that modify the entry of SARS-CoV-2 into human cells, and ACE2 is expressed in multiple organ systems including the lungs, intestine, heart, kidney, and the testis. SARSCoV- 2 has been detected in multiple organs. However, whether the virus exists in the testis remains controversial. In this report we looked at the SARS-CoV-2 test outcomes of semen samples from COVID-19 male patients, we found that outcome was controversial in different literature. We conclude that SARS-CoV-2 does not exist in the test is most likely, but it causes damage to testicular tissue instead.