Isolated and Percutaneous Hepatic Perfusion for Unresectable Liver Metastases: A Systematic Review

1. Abstract

Liver metastases may be difficultly to manage by operative or ablative therapy, and systemic chemotherapy has usually poor results. Therefore, regional therapies have been introduced, as an alternative of systemic chemotherapy. Isolated Hepatic Perfusion (IHP) is a regional therapy which allows the delivery of high doses of chemotherapeutic agents and at the same time systemic toxicity is avoided. Recently, a novel alternative to surgical IHP has been introduced, namely Percutaneous Hepatic Perfusion (PHP) which follows the principles of minimally invasive interventions.