Role of Epigenetics in Predicting the Impact of Hyper Gravity on Cardiovascular Tissues During Space Flight

1. Abstract

The safety of hyper gravity exposure on heart muscle is still missing. Here, we attempt to provide a brief overview of epigenomic and epigenetic mechanisms in light of transcriptional regulation by DNA methylation and its role in cardiovascular disease (CVD). The objective is to identify some of the complex changes that these tissues undergo that are relevant to the experiences of astronauts who are subjected to long-term space travel and following their subsequent return to earth. A comprehensive understanding of the different vascular equilibria defined by gene expressions that are induced in gravity and microgravity and the transitions between them may result in the design of better countermeasures.