Laparoscopic Surgery has brought about a revolution in the approach to various diseases demanding surgical intervention. The paradigm shifts towards laparoscopic surgery compared to conventional surgery has attained acceptance both amongst the patient and operating surgeon. However, this technique is not bereft of its set of complications. Amongst them the least talked about is Port site infection. It’s an infrequent complication which cannot be ignored, as this may undermine the benefits of the laparoscopic technique. Moreover, the complication is not life threatening but definitely leaves an err for the surgeon as it affects the postoperative quality of life and spoils the aesthesis of the surgery. Breach in asepsis resulting in bacterial infection and the rapidly emerging multidrug resistant atypical mycobacterium are a constant threat. This article focuses on the diagnosis, current available treatment options and measures that can be taken to prevent its occurrence. The article emphasis the need on more research work and guidelines to be established pertaining to the techniques required for sterilization of laparoscopic instruments.