Colorectal cancer is the fourth most common cancer in the world. The lung is the second most common site of metastasis. It is suggested that surgical resection is an effective treatment for hepatic metastasis from colorectal cancer, however, the efficiency of surgical treatment for pulmonary metastasis from colorectal cancer is still in dispute. Here we present a case of pulmonary metastasis from colon cancer, that treated by thoracoscopic resection combined with laparoscopic surgery synchronously after four periods of neoadjuvant chemotherapy. The patient is uneventful presently.