Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for dedifferentiated subtype. We report the case of a 44â€‘yearâ€‘old African woman, healed from SARS-Covid, who presented with a 8 cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections. Histological test confirmed diagnosis of dedifferentiated primary pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days. On four months follow up the patient was still alive and without evidence of disease. More studies have to be conducted because very few cases are reported in literature.