Neuroendocrine breast cancer is a rare type of breast tumour with the incidence of less than 0.1%. In most cases, neuroendocrine breast cancers are hormone receptors positive and HER2 negative. We present a rare case of a 69-year-old female patient with left breast T3 N1 triple negative neuroendocrine cancer with axillary lymph node metastasis. The patient underwent neoadjuvant chemotherapy with subsequent left mastectomy and sentinel lymph node biopsy 2 months later. The histopathological result showed a complete pathological response to neoadjuvant therapy. Patient made uneventful recovery and underwent treatment with adjuvant radiotherapy. As yet, there are only 7 triple negative neuroendocrine breast cancer to our knowledge in the literature search [1].
