1. Abstract The expansion in Liver Transplantation (LT) selection criteria for Hepatocellular Carcinoma (HCC) has shown acceptable results in survival rate and tumor recurrence. Historical analysis of the results shows that the path taken so far is correct; however, there are still doubts about the limit of this expansion. The acquisition of new selection tools that measure the biological behavior of the tumor, instead of the historic and simple preoperative morphological analysis, has been gaining strength in this expansion. In this context, analyzing the ethical perspective in the use of grafts from living donors is essential in order to seek a risk vs. benefit balance for both donor and recipient.